Isoquinoline → 2-Aminoisoquinolinium Iodide

HRID 1036640

반응식

HRID 1036640 반응식
[NH2:1]OS(O)(=O)=O.[CH:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][N:8]=1.C(=O)([O-])[O-].[K+].[K+].[IH:23]>O>[I-:23].[NH2:1][N+:8]1[CH:9]=[CH:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1

참가 물질

6

반응물 4

HCID 8405IsoquinolineHCID 11430Potassium CarbonateHCID 24841Hydrogen iodideHCID 76284hydroxylamine-O-sulfonic acid

생성물 1

HCID 108586012-Aminoisoquinolinium Iodide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of hydroxylamine-O-sulfonic acid (2) (2 g, 1 equiv), water (10 mL) and isoquinoline (1) (6.3 mL, 3 equiv) was heated at 90° C. for 2-3 h. Potassium carbonate (2.44 g, 1 equiv) was added, and the water was evaporated. Ethanol (20-30 mL) was added to the solid residue, and insoluble potassium sulfate was filtered out. Hydroiodic acid (57%-67%, 1.34 mL, 1 equiv) was added to the filtrate, and the resulting solution was placed in a freezer. The precipitate was filtered out, washed with ethanol, and dried in vacuo. Isolated products were used as such in further reactions. Yield of the product was 1.78 g.

후처리

  1. customthe water was evaporated
  2. additionEthanol (20-30 mL) was added to the solid residue, and insoluble potassium sulfate
  3. filtrationwas filtered out
  4. filtrationThe precipitate was filtered out
  5. washwashed with ethanol
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-f8ce45c2a6ab4a57bf8d7f94db905dd5
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546426B2

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