Hydrochloric Acid → 2-Amino-3-chloro-5-fluorobenzoic acid

HRID 1041729노트

반응식

HRID 1041729 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([F:13])[CH:5]=[C:6]2[C:10]=1[NH:9]C(=O)[C:7]2=[O:12].[OH:14]O.Cl>[OH-].[Na+]>[NH2:9][C:10]1[C:2]([Cl:1])=[CH:3][C:4]([F:13])=[CH:5][C:6]=1[C:7]([OH:12])=[O:14]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 167936797-Chloro-5-fluoroindoline-2,3-dione

생성물 1

HCID 289741482-Amino-3-chloro-5-fluorobenzoic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 7-chloro-5-fluoro-1H-indole-2,3-dione (270 mg) in 1 M sodium hydroxide solution (5 mL) was treated with 30% hydrogen peroxide (5 mL) via dropwise addition. After one hour of stirring, the reaction was acidified with HCl to pH 1, and extracted three times with ethyl acetate. The combined organic layers were dried with sodium sulfate, and concentrated in vacuo to provide 200 mg of 2-amino-3-chloro-5-fluoro-benzoic acid.

후처리

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe combined organic layers were dried with sodium sulfate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0c31c0868b74449e943750cf469db363
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552186B2

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