Pyridine → 3'-Methylcinnamanilide

HRID 1045353

반응식

HRID 1045353 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:24])[CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>ClCCl>[C:4]1([CH3:8])[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:15](=[O:24])[CH:16]=[CH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7934m-ToluidineHCID 660233-Phenylprop-2-enoyl chloride

생성물 1

HCID 5830183'-Methylcinnamanilide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

m-Toluidine (5 g, 46.64 mmol) and pyridine (3.77 mL, 46.64 mmol) were dissolved in dry dichloromethane (25 mL). To the reaction mixture, cinnamoyl chloride (7.72 g, 46.64 mmol) was added and stirred for 3 h at 0° C. The reaction mixture was extracted with dichloromethane washing with water and 2N HCl. The solvent was removed and the crude product was used in the next step without further purification.

후처리

  1. extractionThe reaction mixture was extracted with dichloromethane washing with water and 2N HCl
  2. customThe solvent was removed
  3. customthe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-14ca28f2f70a417195f49f94d34eea8b
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569282B2

연결된 노트

불러오는 중…