Triphenylphosphine → HCID 67508166, 화합물

HRID 1050279노트

반응식

HRID 1050279 반응식
[Br:1]N1C(=O)CCC1=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O[C@H:29]1[CH2:34][C@H:33]2[C@H:35]3[C@H:44]([CH2:45][CH2:46][C@:31]2([CH3:32])[CH2:30]1)[C:43]1[CH:42]=[CH:41][C:40]([O:47][CH3:48])=[CH:39][C:38]=1[CH2:37][CH2:36]3>ClCCl>[Br:1][C@@H:29]1[CH2:34][C@H:33]2[C@H:35]3[C@H:44]([CH2:45][CH2:46][C@:31]2([CH3:32])[CH2:30]1)[C:43]1[CH:42]=[CH:41][C:40]([O:47][CH3:48])=[CH:39][C:38]=1[CH2:37][CH2:36]3

참가 물질

5

반응물 3

HCID 11776TriphenylphosphineHCID 67184N-bromobutanimideHCID 2275963-Methoxyestra-1(10),2,4-trien-16-ol

생성물 1

HCID 67508166HCID 67508166, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

To a stirred suspension of 2.67 g (15.0 mmol) N-bromosuccinimide in 18 ml dry dichloromethane, a solution of 3.93 g (15.0 mmol) triphenylphosphine in 18 ml dry dichloromethane is added dropwise at 10° C. After 5 min, 1.72 g (6.0 mmol) 16β-hydroxy-3-methoxy-estra-1,3,5(10)-triene are added and the mixture is stirred at room temperature for 2 h. After column chromatography of the reaction product on silica gel (60 g) using 300 ml of dichloromethane, the target compound is obtained in the form of colorless crystals.

후처리

  1. customthe target compound is obtained in the form of colorless crystals

출처 및 근거

ORD 기록
ord-13c5dc10842b4a0388704ed3485e495c
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09382288B2

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