Methyl iodide → 6-Bromo-1,3-dimethyl-1H-indole

HRID 1051490

반응식

HRID 1051490 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[H-].[Na+].[CH3:14]I>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][N:8]2[CH3:14])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 534029586-Bromo-3-methyl-1H-indole

생성물 1

HCID 233835116-Bromo-1,3-dimethyl-1H-indole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 6-bromo-3-methyl-1H-indole (200 mg, 0.95 mmol) in DMF (8 mL) was added NaH (114 mg, 2.85 mmol, m %/60%). The mixture was stirred at room temperature for 1 h before the addition of MeI (162 mg, 1.14 mmol). The system was stirred at room temperature for 4 h then the mixture was quenched with water and extracted with EtOAc. The organic layer was concentrated to give crude product which was used in next step without further purification. LCMS (m/z): 224.1 [M+H]+.

후처리

  1. customthe mixture was quenched with water
  2. extractionextracted with EtOAc
  3. concentrationThe organic layer was concentrated
  4. customto give crude product which
  5. customwas used in next step without further purification

출처 및 근거

ORD 기록
ord-bd6104608632445aabcb26bc882c55c3
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388173B2

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