Methyl 3-bromobenzoate → m-Bromobenzohydrazide

HRID 1052603

반응식

HRID 1052603 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](OC)=[O:6].O.[NH2:13][NH2:14]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:13][NH2:14])=[O:6]

참가 물질

4

반응물 2

HCID 12070Methyl 3-bromobenzoateHCID 24654Hydrazine hydrate (1:1)

생성물 1

HCID 520941m-Bromobenzohydrazide수율 90%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

Methyl 3-bromobenzoate (2 g, 9.3 mmol) was dissolved in 25 ml ethanol. Hydrazine hydrate (4.5 ml, 92.9 mmol) was added and the reaction was stirred at 80° C. overnight. The reaction mixture was evaporated under reduced pressure and a white solid was formed. This solid was washed with water and diethyl ether and dried in the vacuum oven to afford 1.8 g (90% yield) of the title compound. Purity 100%.

후처리

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customa white solid was formed
  3. washThis solid was washed with water and diethyl ether
  4. customdried in the vacuum oven

출처 및 근거

ORD 기록
ord-c5dec2be34f44a01b83b9a791a8ab349
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388189B2

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