N-bromobutanimide → 3-(Bromomethyl)-6-phenylpyridazine

HRID 1054111

반응식

HRID 1054111 반응식
[CH3:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.C1C(=O)N([Br:21])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:21][CH2:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 113787443-Methyl-6-phenylpyridazine

생성물 1

HCID 667174453-(Bromomethyl)-6-phenylpyridazine

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

Synthesized using compound 65b (982 mg, 5.77 mmol), NBS (1.13 g, 6.35 mmol) and DBPO (70 mg, 0.29 mmol) in carbon tetrachloride according to Method A. Crude product was purified by flash chromatography on silica-gel using hexane/ethyl acetate (4:1) as eluent. Product was used directly in the next step without further characterization. Orange solid. Yield: 53 mg, 4%. (ESI): m/z=250.67 [M+H]+.

후처리

  1. customSynthesized
  2. customCrude product was purified by flash chromatography on silica-gel

출처 및 근거

ORD 기록
ord-e12083880c59418886cef06b3e62e0f5
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394290B2

연결된 노트

불러오는 중…