Pyruvic Acid → HCID 178432270, 화합물

HRID 1056243

반응식

HRID 1056243 반응식
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](O)(=[O:14])[C:11]([CH3:13])=O>CO>[Cl:9][C:3]1[C:2]2=[N:1][C:10]([OH:14])=[C:11]([CH3:13])[N:8]=[C:7]2[CH:6]=[CH:5][N:4]=1

참가 물질

4

반응물 2

HCID 1060Pyruvic AcidHCID 2857362-Chloropyridine-3,4-diamine

생성물 1

HCID 178432270HCID 178432270, 화합물수율 65.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

A mixture of 3,4-diamino-2-chloropyridine (2.1 g, 14.63 mmol) (Sigma Aldich) and pyruvic acid (1.22 mL, 17.55 mmol) (Acros, New Jersey) in MeOH (40 mL) in a sealed glass tube was heated at 50° C. for 2 h. The mixture was cooled to RT and the solvent was removed in vacuo. The residue was triturated with ether and the suspension was filtered to give 1.88 g of crude product. MS (ESI, pos. ion) m/z: 196.1 (M+1).

후처리

  1. temperatureThe mixture was cooled to RT
  2. customthe solvent was removed in vacuo
  3. customThe residue was triturated with ether
  4. filtrationthe suspension was filtered

출처 및 근거

ORD 기록
ord-5c3cc1e123fc447d8c33780bcb59abdc
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394297B2

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