Hydrochloric Acid → 2-(4-Chlorophenyl)nicotinic acid

HRID 1058319노트

반응식

HRID 1058319 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([OH:12])=[O:11])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15318002Methyl 2-(4-chlorophenyl)nicotinate

생성물 1

HCID 136013732-(4-Chlorophenyl)nicotinic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution containing methyl 2-(4-chlorophenyl)nicotinate from the previous step (6.0 g, 24.2 mmol) in methyl alcohol (30 mL) was added 1N sodium hydroxide (29 mL). The mixture was stirred at room temperature overnight then neutralized with 1N hydrochloric acid (29 mL), evaporated in vacuo and dried overnight to yield the solid 2-(4-chlorophenyl)nicotinic acid (7.3 g, Theo. Yield=5.65 g, balance is NaCl; HPLC RT=2.17 min; LC-MS m/z=234).

후처리

  1. customevaporated in vacuo
  2. customdried overnight

출처 및 근거

ORD 기록
ord-e522d7fb69e74804a905a8e2baac2be9
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06515011B2

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