Dimethylformamide → N-[(1H-imidazol-2-yl)methyl]acetamide

HRID 1059387노트

반응식

HRID 1059387 반응식
Cl.Cl.[NH2:3][CH2:4][C:5]1[NH:6][CH:7]=[CH:8][N:9]=1.CN(C)C=O.[H-].[Na+].[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[NH:6]1[CH:7]=[CH:8][N:9]=[C:5]1[CH2:4][NH:3][C:17](=[O:19])[CH3:18]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 24758Sodium hydrideHCID 124178631H-imidazol-2-ylmethanamine dihydrochloride

생성물 1

HCID 18670192N-[(1H-imidazol-2-yl)methyl]acetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

0.34 g of 2-aminomethylimidazole dihydrochloride was added to 20 ml of N,N-dimethylformamide in a nitrogen atmosphere. Under ice-cooling, 0.40 g of sodium hydride (60% oily) was added thereto and the resulting mixture was subjected to ultrasonication for 30 minutes. To the reaction mixture were added 20 ml of pyridine and 10 ml of acetic anhydride and the obtained mixture was stirred at room temperature for 2 days. After concentrating under reduced pressure, the residue was distributed into water and ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The extract was concentrated under reduced pressure to thereby give 0.24 g of the title compound as a pale brown solid.

후처리

  1. temperatureUnder ice-cooling
  2. customthe resulting mixture was subjected to ultrasonication for 30 minutes
  3. concentrationAfter concentrating under reduced pressure
  4. washThe organic layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationThe extract was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4d6a00c696fe4de29020fd3a793d9c96
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518423B1

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