Acetic Anhydride → 4-Benzyl-2-phenyl-2-oxazolin-5-one

HRID 1061659

반응식

HRID 1061659 반응식
[C:1]([NH:9][CH:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>>[C:2]1([C:1]2[O:20][C:18](=[O:19])[CH:10]([CH2:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:9]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 273362N-Benzoyl-DL-phenylalanine

생성물 1

HCID 27566504-Benzyl-2-phenyl-2-oxazolin-5-one수율 85.5%

반응 조건

온도
80 °C

실험 절차

A suspension of N-benzoyl-DL-phenylalanine (5.39 g) and acetic anhydride (12.3 g) is stirred at 80° C. for 40 minutes under a nitrogen atmosphere. The reaction mixture is concentrated under reduced pressure to give the titled reference compound (4.30 g).

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-92de09d394204087a6759572d4dc5add
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960575B2

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