Hydrochloric Acid → {(3RS)-4-Acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}acetic acid

HRID 1061673노트

반응식

HRID 1061673 반응식
[OH-].[Li+].[C:3]([N:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]([CH2:18][C:19]([O:21]CC)=[O:20])[C:8](=[O:24])[CH:7]1[CH:25]([CH3:27])[CH3:26])(=[O:5])[CH3:4].Cl>C(O)C>[C:3]([N:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]([CH2:18][C:19]([OH:21])=[O:20])[C:8](=[O:24])[CH:7]1[CH:25]([CH3:27])[CH3:26])(=[O:5])[CH3:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 21302833Ethyl {(3RS)-4-acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazine-1-yl}acetate

생성물 1

HCID 22284314{(3RS)-4-Acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}acetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A 4 N aqueous lithium hydroxide solution (0.4 ml) is added to a solution of ethyl {(3RS)-4-acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}acetate (185 mg, Reference compound No. 50-1) in ethanol (5 ml), and the mixture is stirred for 35 minutes. To the reaction mixture is added 1 N hydrochloric acid to acidify the system, and the whole is extracted with ethyl acetate. The extract is washed with saturated brine and dried over anhydrous magnesium sulfate. The extract is concentrated under reduced pressure to give the titled reference compound (167 mg).

후처리

  1. extractionthe whole is extracted with ethyl acetate
  2. washThe extract is washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationThe extract is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-dd6bc8da0bd54efdbad36ff9f2863d88
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960575B2

반응 노트

불러오는 중…