tert-Butanol → [1,1'-Biphenyl]-4-ol, 3-(1,1-dimethylethyl)-

HRID 1062524노트

반응식

HRID 1062524 반응식
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:14](O)([CH3:17])([CH3:16])[CH3:15].CCCCCC>C1(C)C=CC=CC=1>[C:14]([C:11]1[CH:12]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]=[CH:9][C:10]=1[OH:13])([CH3:17])([CH3:16])[CH3:15]

참가 물질

5

반응물 3

HCID 6386tert-ButanolHCID 71034-HydroxybiphenylHCID 8058Hexane

생성물 1

HCID 162519[1,1'-Biphenyl]-4-ol, 3-(1,1-dimethylethyl)-수율 69%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

Into a 300 ml reactor thoroughly dried and purged with nitrogen, 34.04 g (200.0 mmol) of 4-phenylphenol, 3.40 g of Umberist-15E (trade name, available from Organo Co.) and 150 ml of toluene were introduced. To the reactor, a solution containing 48.20 g (200.0 mmol) of t-butyl alcohol diluted with 10 ml of a toluene was dropwise added at 105° C., followed by stirring for 16 hours. After the system was cooled to room temperature, the solution was introduced into 500 ml of hexane and filtered with washing with hexane. After concentration, the resulting liquid was purified by silica gel column chromatography to obtain 31.15 g (yield: 69%) of 2-t-butyl-4-phenylphenol.

후처리

  1. customInto a 300 ml reactor thoroughly dried
  2. additionwere introduced
  3. additionwas dropwise added at 105° C.
  4. filtrationfiltered
  5. washwith washing with hexane
  6. concentrationAfter concentration
  7. customthe resulting liquid was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-18e6adcb686c446cb2dcda0aa7674e4a
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962890B2

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