Hydrochloric Acid → 4-PHENYL-1-PIPERAZINECARBOTHIOAMIDE

HRID 1062648노트

반응식

HRID 1062648 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13]([NH:15]C(=O)OCC)=[S:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH-].[Na+]>>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[S:14])[NH2:15])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1518349ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

생성물 1

HCID 20517984-PHENYL-1-PIPERAZINECARBOTHIOAMIDE수율 63%

반응 조건

온도
80 °C

실험 절차

Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate (13 g, 44 mmol) was added to conc. hydrochloric acid (44 mL) and the mixture was stirred at 80° C. for 2 h. The reaction mixture was made basic with 8N aqueous sodium hydroxide solution and the crystals were collected by filtration. The crystals were washed with water and dried to give the title compound (6.1 g, yield 63%).

후처리

  1. filtrationthe crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried

출처 및 근거

ORD 기록
ord-39c6e7e35fd646cc9aeb751855e24757
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962933B1

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