Hydrochloric Acid → 2-Propoxybenzoic Acid
반응식
[CH2:1]([O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])[CH2:2][CH3:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])[CH2:2][CH3:3]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of methyl 2-(propyloxy)benzoate (841 mg) in methanol (20 ml) was added 2N sodium hydroxide solution (5 ml) and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was acidified with 6N hydrochloric acid to pH 4 and organic solvent was removed by evaporation. The aqueous layer was diluted with water and extracted with chloroform. The extract was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to give 2-(propyloxy)benzoic acid as colorless oil (756 mg).
후처리
- customwas removed by evaporation
- additionThe aqueous layer was diluted with water
- extractionextracted with chloroform
- washThe extract was washed with brine
- dry with materialdried over magnesium sulfate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-56a5c324676a4d0897f0aba5a1cacc35
- 출처 데이터셋
- uspto-grants-2005_11
- 특허 번호
- US06967197B2
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