Hydrochloric Acid → 3-(Pyridin-4-yl)propanoic acid

HRID 1064017

반응식

HRID 1064017 반응식
C([NH:4][C:5]1[CH:17]=[CH:16][C:8]2SC3C=CC=[CH:12][C:11]=3[C:7]=2[CH:6]=1)(=O)C.[OH-:18].[K+].Cl.[OH2:21]>C(O)C>[N:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH2:16][C:17]([OH:21])=[O:18])=[CH:11][CH:12]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 1086272-Acetamidodibenzothiophene

생성물 1

HCID 2332433-(Pyridin-4-yl)propanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 3-pyridin-4-ylpropanoate (Method 2; 103.1 g, 576 mmol) in water (400 ml) and ethanol (20 ml) at room temperature was added potassium hydroxide (60 g, 1600 mmol). After 18 hours hydrochloric acid (100 ml) was added to give a white solid. Yield 62.8 g (73%). NMR 8.38 (d, 2H), 7.21 (d, 2H), 2.70 (t, 2H), 2.52 (t, 2H); m/z 152.2.

후처리

  1. customto give a white solid

출처 및 근거

ORD 기록
ord-50519d7a41d24d5cb0afee1d39e0f1aa
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06967216B2

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