Pyridine → HCID 69355802, 화합물

HRID 1064080노트

반응식

HRID 1064080 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:13]1[CH:18]=[CH:17][C:16]([CH:19]=O)=[CH:15][CH:14]=1.[C:21]([O:24]C(=O)C)(=[O:23])C.N1C=CC=CC=1>C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:19][C:16]2[CH:15]=[CH:14][N:13]=[CH:18][CH:17]=2)[C:10](=[O:12])[C:21]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

7

반응물 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 133894-PyridinecarboxaldehydeHCID 798743,4-Dichlorophenylacetic acid

생성물 1

HCID 69355802HCID 69355802, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

반응 조건

온도
120 °C

실험 절차

To mixture of (3,4-diChloro-phenyl)-acetic acid 10.3 g and pyridine-4-carbaldehyde 5.25 mL was added acetic anhydride 6 mL and pyridine 6 mL. The reaction mixture was heated to 120° C. for 2 hours and cooled down to room temperature. Water and ethyl acetate were added. The solid formed was filtered, washed with water and ethyl acetate and dried to afford the title compound 10.2 g as a light yellow solid. MS (ES+): 292 (M+H)+.

후처리

  1. temperaturecooled down to room temperature
  2. customThe solid formed
  3. filtrationwas filtered
  4. washwashed with water and ethyl acetate
  5. customdried

출처 및 근거

ORD 기록
ord-f6a6dd6deb874fbe92a88efe556fddc6
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06967254B2

반응 노트

불러오는 중…