Methyl iodide → HCID 22274384, 화합물

HRID 1064429

반응식

HRID 1064429 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[Cl:11])[NH:7][C:6](=[O:12])[C:5]2=[O:13].[H-].[Na+].[H][H].I[CH3:19]>CN(C=O)C.C(O)(=O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[Cl:11])[N:7]([CH3:19])[C:6](=[O:12])[C:5]2=[O:13]

참가 물질

8

반응물 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 110093415,6-dichloro-1H-indole-2,3-dioneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22274384HCID 22274384, 화합물수율 81%

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a solution of 5,6-dichloroisatin (0,15 g; 0.7 mmol) in anhydrous DMF (5 ml) was added sodium hydride (40 mg, 60% dispersion in mineral oil). When the evolution of hydrogen had ceased iodomethane (0.1 ml) was added and the mixture was stirred for 20 min. at ambient temperature. Water (15 ml) and glacial acetic acid (0.1 ml) were added and the product was filtered off, washed with water and dried to yield 5,6-dichloro-1-methylisatin (0.13 g, 81%). The following compounds were prepared analogously: 4,5-dichloro-1-methylisatin (2b) from 4,5-dichloroisatin, and 6,7-dichloro-1-methylisatin from 6,7-dichloroisatin.

후처리

  1. additionwas added
  2. filtrationthe product was filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-2dd4f14ba8ea4157b63e9421531775bc
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969729B2

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