Acetic Acid → 4-Methylsulfonylacetophenone

HRID 1065

반응식

HRID 1065 반응식
[O-][Mn](=O)(=O)=O.[K+].[CH3:7][C:8]([C:10]1[CH:15]=[CH:14][C:13](SC)=[CH:12][CH:11]=1)=[O:9].[S:18]([O-:21])([O-])=[O:19].[Na+].[Na+].[C:24](O)(=O)C>O>[CH3:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([S:18]([CH3:24])(=[O:21])=[O:19])=[CH:12][CH:11]=1)=[O:9]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 24437Sodium SulfiteHCID 745011-(4-(Methylthio)phenyl)ethan-1-oneHCID 516875Potassium Permanganate

생성물 1

HCID 825294-Methylsulfonylacetophenone

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.

후처리

  1. customto return to room temperature
  2. waitThis is left
  3. customThe solid obtained
  4. filtrationis filtered off
  5. washwashed copiously with water
  6. customrecrystallized from 95% ethanol

출처 및 근거

ORD 기록
ord-6d44d87ee23a4984ad13cff1877a23a4
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723485

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