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Methyl iodide → 1-Methyl-6-(4-phenylmercapto-butoxy)-3,4-dihydro-carbostyril

HRID 1065349
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반응식

HRID 1065349 반응식
[C:1]1([S:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[CH3:26]I>CN(C)C=O.O>[CH3:26][N:19]1[C:20]2[C:15](=[CH:14][C:13]([O:12][CH2:11][CH2:10][CH2:9][CH2:8][S:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:22][CH:21]=2)[CH2:16][CH2:17][C:18]1=[O:23]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 248459066-(4-Phenylmercapto-butoxy)-3,4-dihydro-carbostyril

생성물 1

HCID 539875161-Methyl-6-(4-phenylmercapto-butoxy)-3,4-dihydro-carbostyril

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

16.2 gm of 6-(4-phenylmercapto-butoxy)-3,4-dihydro-carbostyril were dissolved in 100 ml of dimethylformamide, and 4.8 gm of a 50% sodium hydride suspension in paraffin oil were added to this solution. After addition of 12.5 ml of methyl iodide, the mixture was stirred for 3 hours at room temperature, diluted with water and extracted with chloroform. The evaporation residue of the chloroform extract was recrystallized with methanol in the presence of activated charcoal.

후처리

  1. extractionextracted with chloroform
  2. extractionThe evaporation residue of the chloroform extract
  3. customwas recrystallized with methanol in the presence of activated charcoal

출처 및 근거

ORD 기록
ord-5b8012e57167458399dc9e0085829a52
출처 데이터셋
uspto-grants-1982_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04329347

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