Hydrochloric Acid → S,S-Hexanediyldi-L-cysteine

HRID 1065749노트

반응식

HRID 1065749 반응식
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]OS(C)(=O)=O)(=O)=O.Cl.[NH2:18][C@H:19]([C:22]([OH:24])=[O:23])[CH2:20][SH:21].[OH-:25].[Na+].Cl>O.C(O)C>[CH2:11]([S:21][CH2:20][C@@H:19]([C:22]([OH:23])=[O:25])[NH2:18])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][S:21][CH2:20][C@@H:19]([C:22]([OH:24])=[O:23])[NH2:18]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 60960Cysteine HydrochlorideHCID 1457351,6-Hexanediol, dimethanesulfonate

생성물 1

HCID 53471696S,S-Hexanediyldi-L-cysteine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

At 70° C., under nitrogen, a mixture of 137 g of 1,6-hexanediyl dimethanesulfonate and 175.5 g of cysteine-hydrochloride monohydrated in 1.5 l of water containing a little ethanol is agitated. There is then slowly added a solution of 5 N NaOH so that the pH of the reaction mixture is maintained between 8.5 and 9.5. At the end of the reaction the mixture is acidified to pH 5.2 with a solution of HCl. The precipitate is filtered, washed thoroughly with water, then dried and analyzed.

후처리

  1. temperatureis maintained between 8.5 and 9.5
  2. customAt the end of the reaction the mixture
  3. filtrationThe precipitate is filtered
  4. washwashed thoroughly with water
  5. customdried

출처 및 근거

ORD 기록
ord-6a78a057348846899f816142eb81995d
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04331656

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