Chloroform → HCID 21199122, 화합물

HRID 1066282

반응식

HRID 1066282 반응식
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[C:4]#[N:5].[Br:11]Br.C(Cl)(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>O>[Br:11][C:9]1[C:2]([CH3:1])=[C:3]([C:6]([CH3:10])=[CH:7][CH:8]=1)[C:4]#[N:5]

참가 물질

6

반응물 4

HCID 6212ChloroformHCID 24408BromineHCID 810572,6-DimethylbenzonitrileHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 21199122HCID 21199122, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2,6-dimethylbenzonitrile (5.0 g, 38.0 mmol), bromine (1.9 ml, 38.0 mmol) and chloroform (10 ml) is stirred at room temperature for 24 hours and subsequently heated to 60° C. for 6 hours. Upon cooling down to 0° C., 10 g of AlCl3 are added and the mixture is stirred for 4 hours at 0° C. The reaction mixture is poured into water and extracted with toluene. The organic phase is separated and concentrated and the residue is purified by column chromatography yielding the pure product as brown crystals, 6.2 g, mp. 60° C.

후처리

  1. temperaturesubsequently heated to 60° C. for 6 hours
  2. temperatureUpon cooling down to 0° C.
  3. stirringthe mixture is stirred for 4 hours at 0° C
  4. extractionextracted with toluene
  5. customThe organic phase is separated
  6. concentrationconcentrated
  7. customthe residue is purified by column chromatography

출처 및 근거

ORD 기록
ord-c743b4deb59541ecad943013fd7950f7
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06242498B1

연결된 노트

불러오는 중…