Carbon tetrabromide → 2-(Bromomethyl)-4-chloro-1-fluorobenzene
반응식
[F:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH2:4]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:31]>C(OCC)C>[F:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH2:4][Br:31]참가 물질
5
실험 절차
A solution of 2-fluoro-5-chlorobenzyl alcohol (1.28 g, 7.97 mmol) in diethyl ether (26 ml) was treated with triphenylphosphine (2.72 g, 10.36 mmol), followed by carbon tetrabromide (3.44 g, 10.36 mmol). The resultant suspension was stirred for 3.5 hours, then filtered, washing with diethyl ether. The filtrate was concentrated, then passed through a plug of silica to remove triphenylphosphate. The residue was then purified by liquid chromatography affording 2.0 grams of a clear oil.
후처리
- filtrationfiltered
- washwashing with diethyl ether
- concentrationThe filtrate was concentrated
- customto remove triphenylphosphate
- customThe residue was then purified by liquid chromatography
출처 및 근거
- ORD 기록
- ord-276ce778c1a84462b18a055612b46bc5
- 출처 데이터셋
- uspto-grants-2001_06
- 특허 번호
- US06245761B1
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