Carbon tetrabromide → HCID 21196139, 화합물

HRID 1066829노트

반응식

HRID 1066829 반응식
[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:36]>C(OCC)C>[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][Br:36]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 211961624-(2-Fluoro-5-bromobenzyloxy)butanol

생성물 1

HCID 21196139HCID 21196139, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 4-(2-fluoro-5-bromobenzyloxy)butanol (7.03 g, 26.3 mmol) in diethyl ether (88 ml) was treated with triphenylphosphine (8.97 g, 34.2 mmol) and carbon tetrabromide (11.3 g, 34.2 mmol). The cloudy solution was stirred at ambient temperature for about 30 hours. The precipitate was removed by filtration and the filtrate was concentrated. The desired title intermediate was purified from the filtrate by bulb to bulb distillation.

후처리

  1. customThe precipitate was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. distillationThe desired title intermediate was purified from the filtrate by bulb to bulb distillation

출처 및 근거

ORD 기록
ord-08bfffead2d44ba6b108f68f28ad0cfc
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06245761B1

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