Urea → Carbamazepine

HRID 1067029

반응식

HRID 1067029 반응식
[NH2:1][C:2]([NH2:4])=[O:3].[CH:5]1[CH:6]=[CH:7][C:8]2N[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH:12]=[CH:11][C:9]=2[CH:10]=1>C(O)(=O)C.P(=O)(O)(O)O>[CH:5]1[CH:6]=[CH:7][C:8]2[N:1]([C:2]([NH2:4])=[O:3])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH:12]=[CH:11][C:9]=2[CH:10]=1

참가 물질

5

반응물 2

HCID 1176UreaHCID 9212Dibenz(b,f)azepine

생성물 1

HCID 2554Carbamazepine

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 1004Phosphoric Acid용매

반응 조건

온도
27.5 °C

실험 절차

To a suspension of urea (80 g, 1.333 mols) in acetic acid (100 ml), phosphoric acid (8 ml) was added, followed by iminostilbene (20 g, 0.103 mols), under stirring at 25-30° C. The resulting reaction mixture was worked up according to the method of Example 1 to produce carbamazepine, which was identical to the product of Example 1.

후처리

  1. additionwas added
  2. customThe resulting reaction mixture

출처 및 근거

ORD 기록
ord-4ac90fca99bf43eb8cf1417bbe33bd96
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06245908B1

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