Furan → HCID 22396537, 화합물

HRID 1070382

반응식

HRID 1070382 반응식
[CH:1]12[O:10][CH:7]([CH2:8][CH2:9]1)[CH:6]1[CH:2]2[C:3](=[O:12])[NH:4][C:5]1=[O:11].C1(=O)[NH:17][C:16](=O)[CH:15]=C1.O1C=CC=C1.BrCC#N>CC(C)=O.CN(C=O)C>[O:12]=[C:3]1[N:4]([CH2:15][C:16]#[N:17])[C:5](=[O:11])[CH:6]2[CH:2]1[CH:1]1[O:10][CH:7]2[CH2:8][CH2:9]1

참가 물질

7

반응물 4

HCID 8029FuranHCID 10935MaleimideHCID 11534BromoacetonitrileHCID 23972710-Oxa-4-azatricyclo(5.2.1.02,6)decane-3,5-dione

생성물 1

HCID 22396537HCID 22396537, 화합물

시약·촉매·용매 2

HCID 180Acetone용매HCID 6228Dimethylformamide용매

실험 절차

Synthesis took place in analogy to Example VI a from 10-oxa-4-azatricyclo[5.2.1.02,6]decane-3,5-dione (obtainable from maleimide and furan from Diels-Alder reaction for example as described by Padwa, A.; Dimitroff, M.; Waterson, A. G.; Wu, T.; J Org Chem 1997, 62, 4088-4096 and subsequent hydrogenation as described by Ansell, M. F.; Caton, M. P. L.; North, P. C.; Tetrahedron Lett. 1982, 23, 2811) and bromoacetonitrile with the exception that acetone was used as solvent in place of DMF. The substance was employed as crude product in the next reaction.

후처리

  1. customSynthesis
  2. customfrom Diels-Alder reaction for example
  3. customThe substance was employed as crude product in the next reaction

출처 및 근거

ORD 기록
ord-5397b9d01bdc473a8cd5f7b98554a071
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903089B1

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