Sodium Hydroxide → 2-(Pyrimidin-2-yloxy)acetic acid

HRID 1070518

반응식

HRID 1070518 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([O:11]CC)=[O:10].[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([OH:11])=[O:10]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22396258Ethyl 2-pyrimidinyloxyacetate

생성물 1

HCID 5662722-(Pyrimidin-2-yloxy)acetic acid수율 58.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2-pyrimidinyloxyacetate (1.4 g) was dissolved in ethanol (10 ml). Sodium hydroxide (2M aq) was added and the mixture was stirred for 64 h. The solvent was evaporated and the residue was dissolved in water, filtered and the acidified with concentrated hydrochloric acid. The resulting precipitate was collected and dried to give the subtitle compound (0.698 g).

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in water
  3. filtrationfiltered
  4. customThe resulting precipitate was collected
  5. customdried

출처 및 근거

ORD 기록
ord-fde72d6116224d3081aa845e2d8ee2c7
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903085B1

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