Isobutyryl chloride → 6,7-Dimethoxy-2-isobutyrylnaphthalene

HRID 1070668노트

반응식

HRID 1070668 반응식
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[C:15](Cl)(=[O:19])[CH:16]([CH3:18])[CH3:17].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:14][O:13][C:12]1[CH:11]=[C:10]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[CH:6]=[C:7]([C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])[CH:8]=[CH:9]2

참가 물질

5

반응물 3

HCID 62325Isobutyryl chlorideHCID 6047082,3-DimethoxynaphthaleneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 114142376,7-Dimethoxy-2-isobutyrylnaphthalene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The solution of 2,3-dimethoxynaphthalene (16.5 g ), isobutyroylchloride (12.5 g) and aluminum chloride (15.7 g) in methylene chloride (200 ml) was stirred at ambient temperature overnight. The solution was then washed with saturated sodium bicarbonate and water, dried with sodium sulfate and evaporated. Finally the crude product was triturated with ether. Yield: 13.5 g, melting point 103-105° C.

후처리

  1. washThe solution was then washed with saturated sodium bicarbonate and water
  2. dry with materialdried with sodium sulfate
  3. customevaporated
  4. customFinally the crude product was triturated with ether

출처 및 근거

ORD 기록
ord-73fdc15dc46c40ffafb067fddaaf97bf
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903114B2

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