Triethylamine → 2,3-Dihydro-1H-indole-1-carbonyl chloride
반응식
[O:1]=[C:2]([Cl:8])OC(Cl)(Cl)Cl.[NH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1.C(N(CC)CC)C>ClCCl>[N:9]1([C:2]([Cl:8])=[O:1])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
22.5 mmol of diphosgene dissolved in 90 ml of dichloromethane are cooled to 0° C.; there are then added 45 mmol of indoline, and then 67.5 mmol of triethylamine, while maintaining the temperature at 0° C. After 12 hours at ambient temperature, the mixture is filtered and the filtrate is concentrated under reduced pressure.
후처리
- filtrationthe mixture is filtered
- concentrationthe filtrate is concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-12cdfcd323b24e0d8ef491d8ed456d0a
- 출처 데이터셋
- uspto-grants-2005_06
- 특허 번호
- US06903103B2
반응 노트
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