Methyl iodide → HCID 15086005, 화합물

HRID 1073221노트

반응식

HRID 1073221 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[CH2:10][OH:11])[C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[S:5]2.[H-].[Na+].[CH3:18]I>CN(C)C=O>[CH3:18][O:11][CH2:10][C:9]1[N:8]2[C:4]([S:5][C:6]3[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=32)=[N:3][C:2]=1[CH3:1]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 130922Nik 228

생성물 1

HCID 15086005HCID 15086005, 화합물수율 60.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 30 ml of dry dimethylformamide was suspended 2.18 g of 2-methylimidazo[2,1-b]benzothiazole-3-methanol and, 0.50 g of 60% sodium hydride was added to the suspension followed by stirring at room temperature for minutes. After 1.74 g of methyl iodide was added thereto, the mixture was stirred for one hour. Then ice water was added to the reaction mixture followed by extracting with ethyl acetate. After the ethyl acetate was removed, 1.41 g of the title compound was obtained.

후처리

  1. additionwas added to the suspension
  2. stirringthe mixture was stirred for one hour
  3. extractionby extracting with ethyl acetate
  4. customAfter the ethyl acetate was removed

출처 및 근거

ORD 기록
ord-01542132dd454ae284a8761c91dbed3c
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968708

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