Ethyl Thioglycolate → Ethyl (3-phenoxybenzylthio)acetate

HRID 1074057

반응식

HRID 1074057 반응식
C[C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.ClC[C:18]1[CH:23]=[CH:22][C:21]([O:24]C2C=CC=CC=2)=[CH:20][CH:19]=1.CC[O-].[Na+].SCC(OCC)=O>C(O)C>[O:24]([C:15]1[CH:14]=[C:5]([CH:4]=[CH:3][CH:2]=1)[CH2:6][S:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:21]1[CH:22]=[CH:23][CH:18]=[CH:19][CH:20]=1

참가 물질

6

반응물 4

HCID 12185Ethyl ThioglycolateHCID 5209941-(Chloromethyl)-4-phenoxybenzeneHCID 2723922Sodium ethoxideHCID 4107274Ethyl (4-methylbenzylthio)acetate

생성물 1

HCID 53984256Ethyl (3-phenoxybenzylthio)acetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The procedure is as in Example 29 for the preparation of ethyl (4-methylbenzylthio)acetate, starting with 1-chloromethyl-4-phenoxybenzene (21.5 g), a 2M ethanolic solution of sodium ethylate (50 cc) and ethyl 2-mercaptoacetate (12.2 g) in ethanol (200 cc). Ethyl (3-phenoxybenzylthio)acetate (28.8 g) is thereby obtained, and is used in the crude state in the subsequent syntheses.

출처 및 근거

ORD 기록
ord-31facc416b20404fa2052b44a83341a5
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971979

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