Propargyl bromide → HCID 12534513, 화합물

HRID 1075178노트

반응식

HRID 1075178 반응식
[K].[CH3:2][S:3][C:4]1[C:9]([F:10])=[CH:8][NH:7][C:6](=[O:11])[N:5]=1.[CH2:12](Br)[C:13]#[CH:14]>CN(C)C=O>[CH2:14]([N:7]1[CH:8]=[C:9]([F:10])[C:4]([S:3][CH3:2])=[N:5][C:6]1=[O:11])[C:13]#[CH:12]

참가 물질

5

반응물 3

HCID 7842Propargyl bromideHCID 5462222PotassiumHCID 178503576HCID 178503576, 화합물

생성물 1

HCID 12534513HCID 12534513, 화합물수율 71%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The potassium salt of 4-methylthio-5-fluoropyrimid-2-one (0.005 mol) and propargyl bromide (0.06 mol) were stirred together in dimethylformamide (20 ml) for 40 hrs at room temperature. The mixture was then filtered; the filtrate evaporated at reduced pressure (1 mm Hg) and the residue extracted with chloroform (60 ml). The chloroform solution was washed with 1 N NaOH, with water, and dried (MgSO4) before evaporation; yield 71%, m.p. 101°-102° C. (ethyl acetate). (Found: C, 48.50; H, 3.62. Calc. for C8H7SN2O: C, 48.48; H, 3.56).

후처리

  1. filtrationThe mixture was then filtered
  2. customthe filtrate evaporated at reduced pressure (1 mm Hg)
  3. extractionthe residue extracted with chloroform (60 ml)
  4. washThe chloroform solution was washed with 1 N NaOH, with water
  5. dry with materialdried (MgSO4)
  6. custombefore evaporation

출처 및 근거

ORD 기록
ord-022e3d27b56145c0855722b24b8f3648
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04395406

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