Hydrochloric Acid → 2-(6-Formamidopyridin-2-yl)acetic acid

HRID 1075251노트

반응식

HRID 1075251 반응식
[CH:1]([NH:3][C:4]1[N:9]=[C:8]([CH2:10][C:11]([O:13]CC)=[O:12])[CH:7]=[CH:6][CH:5]=1)=[O:2].[OH-].[Na+].O.Cl>C(O)C>[CH:1]([NH:3][C:4]1[N:9]=[C:8]([CH2:10][C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=1)=[O:2]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 13060164HCID 13060164, 화합물

생성물 1

HCID 130601732-(6-Formamidopyridin-2-yl)acetic acid수율 65.7%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of ethyl 2-(6-formamidopyridin-2-yl)acetate (4.4 g.) in ethanol (44 ml.) was added 2 N sodium hydroxide solution [solvent:water (1 part)+ethanol (4 parts] (15.9 ml.) at 18° to 20° C. over 30 minutes, and then the solution was stirred at room temperature for one hour. After 1 N hydrochloric acid (31.7 ml.) was added to the solution, the solution was concentrated under reduced pressure. The residue was extracted with hot ethyl acetate (500 ml.) and the extract was concentrated under reduced pressure. The residue was washed with ethyl acetate to give 2-(6-formamidopyridin-2-yl)acetic acid (2.5 g.), mp 125° to 126° C. (dec.).

후처리

  1. concentrationthe solution was concentrated under reduced pressure
  2. extractionThe residue was extracted with hot ethyl acetate (500 ml.)
  3. concentrationthe extract was concentrated under reduced pressure
  4. washThe residue was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-98804b8ebb9047d08c65ec6ccba29722
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04395411

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