Hydrochloric Acid → HCID 20494720, 화합물

HRID 1075301노트

반응식

HRID 1075301 반응식
[H-].[Na+].[CH:3]([N:6]1[CH:15]2[CH:10]([CH2:11][CH2:12][C:13]([CH3:16])=[CH:14]2)[C:9](=O)[NH:8][C:7]1=[O:18])([CH3:5])[CH3:4].[F:19][C:20]1[CH:25]=[CH:24][C:23]([Mg]Br)=[CH:22][CH:21]=1.Cl>O1CCCC1>[CH:3]([N:6]1[CH:15]2[CH:10]([CH2:11][CH2:12][C:13]([CH3:16])=[CH:14]2)[C:9]([C:23]2[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=2)=[N:8][C:7]1=[O:18])([CH3:5])[CH3:4]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 20494718HCID 20494718, 화합물HCID 178418676HCID 178418676, 화합물

생성물 1

HCID 20494720HCID 20494720, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred suspension of 2.37 g sodium hydride in 45 ml tetrahydrofurane are added portionwise at room temperature 13.32 g 1-isopropyl-7-methyl-4a,5,6,8a-tetrahydro-2,4-(1H)-quinazolindione and the mixture stirred for 45 minutes. 39 ml of a 2N solution of 4-fluorophenyl magnesium bromide in tetrahydrufurane are then added dropwise within 2 hours at an internal temperature of 40° and the resulting suspension stirred at 40° for 15 hours. 23 ml 15% hydrochloric acid are then added under ice cooling and the solvent removed in vacuo. The residue is taken up with water and methylene chloride. The methylene chloride phase is evaporated to dryness to obtain the title compound.

후처리

  1. stirringthe resulting suspension stirred at 40° for 15 hours
  2. customthe solvent removed in vacuo
  3. customThe methylene chloride phase is evaporated to dryness

출처 및 근거

ORD 기록
ord-eed2d5ed1314469eab0cda1878898ecf
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04395550

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