Acetic Anhydride → N-(3-(Pyridin-2-yl)phenyl)acetamide

HRID 1075453노트

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]([CH:11]=[CH:12][CH:13]=1)[NH2:10].[OH-].[Na+].[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([NH:10][C:9]1[CH:11]=[CH:12][CH:13]=[C:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:8]=1)(=[O:18])[CH3:17]

참가 물질

반응물 3

HCID 7918Acetic Anhydride

HCID 14798Sodium Hydroxide

HCID 4595173-(2-Pyridyl)aniline

생성물 1

HCID 53737528N-(3-(Pyridin-2-yl)phenyl)acetamide

실험 절차

A mixture of 2f (5.6g, 32.9mmol) and acetic anhydride (20ml) is stirred at ambient temperature for 1 hour. The mixture is poured into ice-water and rendered alkaline with 10M sodium hydroxide. The product is filtered off, washed with water and dried. Yield:

후처리

filtrationThe product is filtered off
washwashed with water
customdried

출처 및 근거

ORD 기록: ord-2619935c8ef140c9a0e3f1699844ece5
출처 데이터셋: uspto-grants-1999_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05902813

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