1H-1,2,4-Triazole → 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone

반응식

Cl[CH2:2][C:3]([CH2:5]Cl)=[O:4].[NH:7]1[CH:11]=[N:10][CH:9]=[N:8]1>>[N:7]1([CH2:2][C:3](=[O:4])[CH2:5][N:7]2[CH:11]=[N:10][CH:9]=[N:8]2)[CH:11]=[N:10][CH:9]=[N:8]1

참가 물질

반응물 2

HCID 92571H-1,2,4-Triazole

HCID 107931,3-Dichloroacetone

생성물 1

HCID 219821391,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone

실험 절차

According to the Spanish Patent Number ES 549 020 A1 1 mole of 1,3-dichloroacetone is reacted with 2 mole of 1,2,4-triazole, then the 1,3-bis(1,2,4-triazole-1-yl)-propan-2-on obtained with low yield is reacted with 2,4-difluorophenylmagnesium bromide to give fluconazole. The yield is about 45% calculated on the Grignard reagent.

출처 및 근거

ORD 기록: ord-c6da0580259c4980b9f5ec2af98dfe19
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07094904B2

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