Formaldehyde → 1-(Methoxymethyl)-2-pyrrolidinone

HRID 1076194

반응식

HRID 1076194 반응식
[OH:1][CH2:2][N:3]1[CH2:7][CH2:6][CH2:5][C:4]1=[O:8].N1CCC[C:10]1=O.C=O.ClCN1CCCC1=O.C[O-].[Na+]>CO>[CH3:10][O:1][CH2:2][N:3]1[CH2:7][CH2:6][CH2:5][C:4]1=[O:8]

참가 물질

7

반응물 5

HCID 712Formaldehyde2회HCID 120252-PyrrolidoneHCID 849112-Pyrrolidinone, 1-(hydroxymethyl)-HCID 27704972-Pyrrolidinone, 1-(chloromethyl)-HCID 10942334Sodium Methoxide

생성물 1

HCID 136248301-(Methoxymethyl)-2-pyrrolidinone수율 64%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-hydroxymethyl pyrrolidinone is a compound known in the art as an intermediate in the preparation of dyestuffs. As taught in U.S. Pat. No. 3,073,843, this material is prepared by the reaction of pyrrolidinone and formaldehyde or a precursor of formaldehyde. This patent does not suggest the formation of derivatives of this compound however. In addition, Chemical Abstracts, Volume 55, page 27267H (1961) discloses the reaction of N-chloromethyl-2-pyrrolidinone with a mixture of sodium methylate and methanol to yield 64% of N-methoxymethyl-2-pyrrolidinone. Also, Chemical Abstracts, Volume 54, page 1286f (1960) teaches that N-chloromethyl-2-pyrrolidinone can be prepared in 87% yield by treatment of the methylol derivative with SOCl2 in benzene solvent at 8°C.

후처리

  1. customknown in the art as an intermediate in the preparation of dyestuffs

출처 및 근거

ORD 기록
ord-111e7a6cc2cf4bf6b7b416acecfbb6b7
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03956313

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