Acetic Anhydride → 2-(benzenesulfonyl)-3-ethoxyprop-2-enenitrile
반응식
[C:1]1([S:7]([CH2:10][C:11]#[N:12])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:13](OCC)(OCC)[O:14][CH2:15][CH3:16].C(OC(=O)C)(=O)C.C(OCC)(=O)C>CO>[CH2:15]([O:14][CH:13]=[C:10]([S:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)(=[O:8])=[O:9])[C:11]#[N:12])[CH3:16]참가 물질
6
실험 절차
A solution of (phenylsulfonyl)acetonitrile (10.5 g, 0.089 mol) in triethyl orthoformate (21 mL, 0.14 mol) and acetic anhydride (21 mL, 0.2 mol) was heated at 160° C. with removal of ethyl acetate (35 mL). The dark oily residue was dissolved in methanol (60 mL) and the solution was concentrated and recrystallized from hexanes/ethyl acetate to yield (11.98 g, 78%) of the desired product.
후처리
- concentrationthe solution was concentrated
- customrecrystallized from hexanes/ethyl acetate
출처 및 근거
- ORD 기록
- ord-89762a37df2941d59d2cc293b7d3df3f
- 출처 데이터셋
- uspto-grants-1996_08
- 특허 번호
- US05545515
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