Methyl iodide → 2,6-dichloro-7-methyl-7H-purine

HRID 1080671노트

반응식

HRID 1080671 반응식
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([Cl:11])[N:3]=1.[C:12](=O)([O-])[O-].[K+].[K+].[CH3:18]I>CS(C)=O>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:12])[CH:7]=[N:8]2)=[C:4]([Cl:11])[N:3]=1.[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH3:18])=[C:4]([Cl:11])[N:3]=1

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 53244122,6-Dichloropurine

생성물 2

HCID 752812,6-dichloro-7-methyl-7H-purineHCID 17125532,6-dichloro-9-methyl-9H-purine

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

In a manner similar to Preparation A, 9.52 g of 2,6-dichloropurine, 7.65 g of potassium carbonate and 7.86 g of methyl iodide in 65 ml of dimethylsulfoxide gave 1.54 g of 2,6-dichloro-7-methylpurine and 4.7 g of 2,6-dichloro-9-methylpurine.

출처 및 근거

ORD 기록
ord-52955fdca6e54de68e1196fe9e2821aa
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05583137

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