홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 4-[6-(Cyclopentyloxycarbonyl)aminobenzimidazol-1-ylmethyl]-3-methoxybenzoic acid

HRID 1080781
노트
인쇄 미리보기

반응식

HRID 1080781 반응식
[CH:1]1([O:6][C:7]([NH:9][C:10]2[CH:11]=[CH:12][C:13]3[N:17]=[CH:16][N:15]([CH2:18][C:19]4[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][C:20]=4[O:29][CH3:30])[C:14]=3[CH:31]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.O1CCCC1.O.[OH-].[Li+].Cl>O.CO>[CH:1]1([O:6][C:7]([NH:9][C:10]2[CH:11]=[CH:12][C:13]3[N:17]=[CH:16][N:15]([CH2:18][C:19]4[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][C:20]=4[O:29][CH3:30])[C:14]=3[CH:31]=2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 14763099Methyl 4-[6-(cyclopentyloxycarbonyl)aminobenzimidazol-1-ylmethyl]-3-methoxybenzoate

생성물 1

HCID 147631014-[6-(Cyclopentyloxycarbonyl)aminobenzimidazol-1-ylmethyl]-3-methoxybenzoic acid수율 78%

시약·촉매·용매 2

HCID 887Methanol용매
HCID 962Water용매

실험 절차

A stirred solution of methyl 4-[6-(cyclopentyloxycarbonyl)aminobenzimidazol-1-ylmethyl]-3-methoxybenzoate in 1:1 v/v tetrahydrofuran:methanol (7 ml.) was treated with water (1.4 ml.) and lithium hydroxide monohydrate (0.3 g.). Stirring was continued at ambient temperature for 4 hours. The solvent was then evaporated. The resultant residue was dissolved in water. The solution obtained was acidified with 10% v/v hydrochloric acid. The resultant precipitate was collected by filtration to give the title compound (0.43 g., 78%). An analytical sample was obtained as a white powder by recrystallization from aqueous ethanol; m.p. 241°-242° C.

후처리

  1. customThe solvent was then evaporated
  2. dissolutionThe resultant residue was dissolved in water
  3. customThe solution obtained
  4. filtrationThe resultant precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-e07220bb985248cd87b4ac73d1115d73
출처 데이터셋
uspto-grants-1996_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05583152

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트