Phosphoric Acid → Diacetylguanine

HRID 1080876

반응식

HRID 1080876 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH:8]1[C:17](=[O:18])[C:16]2[NH:15][CH:14]=[N:13][C:12]=2[N:11]=[C:9]1[NH2:10].P(=O)(O)(O)O.[CH3:24][C:25](OC(C)=O)=[O:26].CC(O)=O.N1C(=O)C2NC=NC=2N=C1N.OP(O)(O)=O>C(O)(=O)C>[C:25]([N:10]([C:5](=[O:7])[CH3:6])[C:9]1[NH:8][C:17](=[O:18])[C:16]2[NH:15][CH:14]=[N:13][C:12]=2[N:11]=1)(=[O:26])[CH3:24]

참가 물질

6

반응물 4

HCID 1004Phosphoric AcidHCID 7918Acetic AnhydrideHCID 135398634Guanine2회HCID 136333567Ac2O AcOH guanine H3PO4

생성물 1

HCID 136360183Diacetylguanine수율 94%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The effect of the ratio of acetic anhydride and acetic acid on the reaction time and yield was also studied. In general, any range of acetic anhydride, acetic acid, guanine and phosphoric acid can be used that provides the desired results. In the present work, it was found that a ratio of 15/10/1/0.05 (ml) of Ac2O/AcOH/guanine/H3PO4 is preferred. It was discovered that guanine could be acetylated using this ratio of reactants at reflux for 15 hours to give diacetylguanine with minimal discoloration in approximately 94% yield.

후처리

  1. customthat provides the
  2. customdesired results
  3. temperatureat reflux for 15 hours

출처 및 근거

ORD 기록
ord-976c28d10c8840548e254ab29039ac45
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05583225

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