Hydrochloric Acid → HCID 11301002, 화합물

HRID 1080912노트

반응식

HRID 1080912 반응식
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[C:16]([OH:20])(=[O:19])[CH:17]=O.[ClH:21]>C(O)(=O)C>[C:11]([C:7]1[CH:8]=[C:9]([CH:17]([Cl:21])[C:16]([OH:20])=[O:19])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15])([CH3:14])([CH3:13])[CH3:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 760Glyoxylic AcidHCID 314052,6-Di-tert-butylphenol

생성물 1

HCID 11301002HCID 11301002, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
10 °C

실험 절차

309.5 g (1.5 Mol) of 2,6-di-tert-butylphenol and 266.5 g (1.8 mol) of 50% aqueous glyoxylic acid are dissolved in 1400 ml of glacial acetic acid. Then, 200 g (5.5 mol) of gazeous hydrogen chloride are introduced into this solution over a period of 2.5 hours under stirring and cooling in an ice bath to keep the temperature in the 10°-25° C. range. The mixture is then stirred at room temperature overnight, cooled to 10° C., the solid is isolated by filtration on a Buechner funnel and washed with 1000 ml water. The slightly yellow and still wet cake of the intermediate product weighs about 565 g.

후처리

  1. temperaturecooling in an ice bath
  2. customin the 10°-25° C. range
  3. stirringThe mixture is then stirred at room temperature overnight
  4. customthe solid is isolated by filtration on a Buechner funnel
  5. washwashed with 1000 ml water

출처 및 근거

ORD 기록
ord-72d04f9cc5324c92a4580f57f502ca5b
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05583247

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