Phthalic Anhydride → 2-(2-Thienylcarbonyl)benzoic acid

HRID 1081327노트

반응식

HRID 1081327 반응식
[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[Cl-].[Al+3].[Cl-].[Cl-].[S:16]1[CH:20]=[CH:19][CH:18]=[CH:17]1>ClCCl>[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:4]([C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[C:1]([OH:6])=[O:11])=[O:5]

참가 물질

5

반응물 3

HCID 6811Phthalic AnhydrideHCID 8030ThiopheneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 2826542-(2-Thienylcarbonyl)benzoic acid수율 61.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a mixture of phthalic anhydride (2.96 g), dichloromethane (10 ml) and aluminum chloride (5.87 g) was added a solution of thiophene (1.6 g) in dichloromethane, in limited amounts, while stirring at room temperature, then the reaction mixture was stirred for one hour at room temperature. The reaction mixture was poured into HCl-ice water, followed by extraction with ethyl acetate. The extract solution was washed with water and dried, then the solvent was distilled off to leave 2-(2-thienylcarbonyl)benzoic acid as colorless crystals (2.72 g).

후처리

  1. stirringthe reaction mixture was stirred for one hour at room temperature
  2. extractionfollowed by extraction with ethyl acetate
  3. washThe extract solution was washed with water
  4. customdried
  5. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-2962e87f8c1945adb12bf8eab97da383
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05585385

반응 노트

불러오는 중…