Stannous Chloride → 2-Chloro-4-hydrazinylbenzonitrile hydrochloride

HRID 1085

반응식

HRID 1085 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([Cl:10])[CH:3]=1.[N:11]([O-])=O.[Na+].Cl[Sn]Cl>C1COCC1.O.Cl>[ClH:10].[Cl:10][C:4]1[CH:3]=[C:2]([NH:1][NH2:11])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

참가 물질

7

반응물 3

HCID 24479Stannous ChlorideHCID 887284-Amino-2-chlorobenzonitrileHCID 23668193Sodium Nitrite

생성물 1

HCID 221118492-Chloro-4-hydrazinylbenzonitrile hydrochloride

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매2회HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
-5 °C

실험 절차

5 g of 4-amino-2-chlorobenzonitrile and 40 ml of concentrated HCl in 30 ml of THF are mixed at -5° C.; 2.26 g of NaNO2 in 30 ml of water are added and the mixture is left stirring for 2 hours, 30 g of SnCl2 ·2H2O in 30 ml of concentrated HCl are then added and stirring is maintained at -5° C. for 30 minutes.

후처리

  1. waitthe mixture is left
  2. stirringstirring

출처 및 근거

ORD 기록
ord-951984be58214825afaa7f028775b4b9
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723483

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