Sodium Carbonate → 3,6,8-Tribromoimidazo[1,2-a]pyrazine

HRID 1086174노트

반응식

HRID 1086174 반응식
[Br:1][C:2]1[N:3]=[C:4]([Br:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:12]N1C(=O)CCC1=O.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:12][C:8]1[N:6]2[CH:7]=[C:2]([Br:1])[N:3]=[C:4]([Br:11])[C:5]2=[N:10][CH:9]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 67184N-bromobutanimideHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

생성물 1

HCID 142076223,6,8-Tribromoimidazo[1,2-a]pyrazine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 0.8 g (2.9 mmol) of 6,8-dibromoimidazo[1,2-a]pyrazine and 1.2 g of N-bromosuccinimide in 40 ml of chloroform is brought to reflux for two hours. After being cooled, the organic solution is treated with aqueous Na2CO3 solution. The chloroform phase is collected and then evaporated. 1 g -(Yld=97%) of 3,6,8-tribromoimidazo[1,2-a]pyrazine (m.p. 161° C.) is obtained.

후처리

  1. temperatureto reflux for two hours
  2. temperatureAfter being cooled
  3. customThe chloroform phase is collected
  4. customevaporated

출처 및 근거

ORD 기록
ord-6ae912ba9eb44bfab634123c48a48334
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05028605

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