Methyl iodide → (1-Methyl-1,2,3,4-tetrahydroquinolin-8-yl)methanol

HRID 1088787노트

반응식

HRID 1088787 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[NH:11][CH2:10][CH2:9][CH2:8]2.[H-].[Na+].[CH2:15]([Li])CCC.CI>O1CCCC1>[CH3:15][N:11]1[C:12]2[C:7](=[CH:6][CH:5]=[CH:4][C:3]=2[CH2:2][OH:1])[CH2:8][CH2:9][CH2:10]1

참가 물질

6

반응물 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 14072927(1,2,3,4-Tetrahydroquinolin-8-yl)methanolHCID 178418339Butyllithium

생성물 1

HCID 15053143(1-Methyl-1,2,3,4-tetrahydroquinolin-8-yl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 8-hydroxymethyl-1,2,3,4-tetrahydroquinoline (8.03 g) and sodium hydride (60% in oil) (1.97 g) was added tetrahydrofuran (100 ml) under ice-cooling and argon atmosphere, and the mixture was stirred for 2 hours at 70° to 75° C. At -70° C., n-butyllithium (20 ml) was added to the reaction mixture by use of a syringe, and 30 minutes after addition, a solution of methyl iodide (6.98 g) in tetrahydrofuran (30 ml) was added thereto, and the mixture was stirred for 20 hours at room temperature. After distilling off tetrahydrofuran, the resulting residue was extracted with chloroform, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the resulting residue was purified by silica gel column chromatography [eluent: n-hexane-ethyl acetate (4:1)]to give 1-methyl-8-hydroxymethyl-1,2,3,4-tetrahydroquinoline (5.00 g).

후처리

  1. temperaturecooling
  2. addition30 minutes after addition
  3. stirringthe mixture was stirred for 20 hours at room temperature
  4. distillationAfter distilling off tetrahydrofuran
  5. extractionthe resulting residue was extracted with chloroform
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationThe solvent was distilled off
  8. customthe resulting residue was purified by silica gel column chromatography [eluent

출처 및 근거

ORD 기록
ord-78fb6607072844dda15dd6097e758e5d
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04963566

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