Hydrochloric Acid → HCID 14839596, 화합물

HRID 1089225노트

반응식

HRID 1089225 반응식
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([S:18][CH2:19][CH3:20])=[C:12]([F:17])[CH:13]=2)[N:8]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>O>[F:17][C:12]1[CH:13]=[C:14]2[C:9](=[N:10][C:11]=1[S:18][CH2:19][CH3:20])[N:8]([C:21]([CH3:23])([CH3:24])[CH3:22])[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:15]2=[O:16]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14839595HCID 14839595, 화합물

생성물 1

HCID 14839596HCID 14839596, 화합물수율 93%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A suspension of 0.23 g (0.65 mmoles) of 6-fluoro-7-ethylthio-(1,1-dimethylethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester in 1 mL of water was treated with 1.3 mL of 1N aqueous sodium hydroxide and the mixture was heated under reflux for 45 minutes. The resulting precipitate was acidified with 1 mL of 2N hydrochloric acid, filtered, washed with water and dried in vacuo at 50° C. to give 0.196 g of titled compound. MP 215° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 45 minutes
  3. filtrationfiltered
  4. washwashed with water
  5. customdried in vacuo at 50° C.

출처 및 근거

ORD 기록
ord-92276669a8f147caaf9adf7008530d5b
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04965273

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