Sodium Hydroxide → 2-Amino-4-(4-morpholinyl)benzonitrile

HRID 1091532

반응식

HRID 1091532 반응식
O.O.[Sn](Cl)Cl.[N:6]1([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[C:14]([N+:20]([O-])=O)[CH:13]=2)[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.[OH-].[Na+]>Cl>[NH2:20][C:14]1[CH:13]=[C:12]([N:6]2[CH2:7][CH2:8][O:9][CH2:10][CH2:11]2)[CH:19]=[CH:18][C:15]=1[C:16]#[N:17]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 61436Stannous chloride dihydrateHCID 134992654-Morpholino-2-nitrobenzonitrile

생성물 1

HCID 134992832-Amino-4-(4-morpholinyl)benzonitrile수율 95.7%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

To a cooled mixture of tin(II) chloride dihydrate 12.8 g (56.7 mmol) in conc. HCl mL with ice bath was added 4-(morpholin-4-yl)-2-nitrobenzonitrile 4.20 g (16.09 mmol) and stirred at room temperature for 2 hours. The reaction mixture was poured into diluted NaOH solution and extracted into ethyl acetate. The organic layer was washed with water and brine, dried over MgSO4 and the solvent was evaporated. The crude product was washed with diethyl ether to give the title compound 3.13 g as off-white solid. Yield 95.0%.

후처리

  1. extractionextracted into ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over MgSO4
  4. customthe solvent was evaporated
  5. washThe crude product was washed with diethyl ether

출처 및 근거

ORD 기록
ord-21ef5eb7f24949b289e1ca76d8b6b19d
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129386B2

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