Hydrochloric Acid → HCID 66593501, 화합물

HRID 1091663노트

반응식

HRID 1091663 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][C:11]#[N:12].[H-].[Na+].Cl[C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1.Cl>C1COCC1.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]1=[C:10]([C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1)[C:11]#[N:12]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 744042-ChloropyrimidineHCID 3424652-(1,3-Benzothiazol-2-yl)acetonitrile

생성물 1

HCID 66593501HCID 66593501, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

2-(Benzothiazol-2-yl)acetonitrile (0.69 g, 4 mmol) was added in portions to a suspension of 95% sodium hydride ((0.21 g, 6 mmol) in THF (12 mL). The resulting yellow suspension was stirred at room temperature for 30 min, and 2-chloropyrimidine (0.45 g, 4 mmol) was added. The mixture was stirred for 3 d, and water was added to the dark solution. The mixture was acidified with 1N hydrochloric acid, and the precipitate that formed was collected by filtration, washed with water and acetonitrile, and dried under vacuum to give 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetonitrile as a brown solid.

후처리

  1. stirringThe mixture was stirred for 3 d
  2. customthe precipitate that formed
  3. filtrationwas collected by filtration
  4. washwashed with water and acetonitrile
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-37ea5497767e4de7b014945facdd8c4a
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129396B2

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