Formaldehyde → HCID 66636594, 화합물

HRID 1093970노트

반응식

HRID 1093970 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH:7]1[CH:11]=[CH:10][CH:9]=[CH:8]1.[CH2:12]=O.[OH-].[Na+]>C(O)(=O)C>[NH:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH2:12][N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 8027PyrroleHCID 8083MorpholineHCID 14798Sodium Hydroxide

생성물 1

HCID 66636594HCID 66636594, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of morpholine (22 mmoles) in acetic acid (10 ml) there is added pyrrole (20 mmoles) dropwise at 0° C. Formaldehyde (37% aq., 20 mmoles) is then added dropwise. The reaction mixture is stirred for 2 hours at ambient temperature. The solution is cooled to 0° C. and is brought to alkaline pH (10-11) using 20% aqueous NaOH solution. After extraction with DCM, the organic phases are washed with water and with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product in the form of a white solid which is used directly in the next Step.

후처리

  1. temperatureThe solution is cooled to 0° C.
  2. extractionAfter extraction with DCM
  3. washthe organic phases are washed with water and with saturated aqueous NaCl solution
  4. dry with materialdried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-8564bc1ae58e4b7ebed9e4f88c5c7d39
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133889B2

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